http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1616924-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dbdea867b9b0d3c922cc65f768a1fca |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 |
| filingDate | 1988-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9abd14bee0c750b044d610548b0c9458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f24eee339535b844d21a74c4701b5802 |
| publicationDate | 1990-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1616924-A1 |
| titleOfInvention | 3-aminopropylglycosides of disaccharides |
| abstract | The invention relates to substituted glycosides of disaccharides, in particular (3-aminopropyl) -3-0- (2-acetamido-2-deoxy-α-D-galactopyranosyl) -β-D-galactopyranoside or (3-aminopropyl) -3-0- (α-D-galactopyranosyl) -β-D-galactopyranoside as ligands of immunosorbents for binding groups of specific antibodies anti-A and anti-B, and can be used in biochemistry. The goal is to create new, more accessible and immobilizing oligosaccharide ligands. The synthesis is carried out, for example, by the reaction of 1,2-di-o-acetyl-3,4,6-0-benzyl-D-galactopyranose with 3-trifluoroacetamidopropanol in CH 2 CL 2 medium in the presence of BF 3 etherate at 0 ° C, followed by isolation of the intermediate product, its hydragenyl at 10% PD / C at 20 ° C, evaporation of the filtered product, dissolving in acetonitrile and addition of benzaldehyde dimethyl acetal, 4-toluenesulfonic acid and then pyridine. The chromatographically separated product is dissolved in CH 2 CL 2 , molecular sieves, silver carbonate and silver perchlorate are added and then 2-azido-3,4,6-tri-o-acetyl-2-deoxy-β-D-galactopyranosyl chloride in a solution of CH 2 CL 2 . The disaccharide chromatographed was dissolved in acetic acid, kept for 2 hours at 70 ° C, evaporated, acetic anhydride was added, and hydrogenolysis was performed on 5% PD / C in methanol. The desired product is also isolated by chromatography. Sorbtsi at the level known. 1 tab. |
| priorityDate | 1988-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.