| abstract |
This invention provides a series of novel heterocyclic carboxamides of formula I in which the group -Y-Z< is selected from -C(ra)=C<, -N=C<, and -CH(Ra)-CH< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture. |