http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1563206-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b50d5c4b9c7fd0ec11f2192c5cbeb93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-382 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-295 |
| filingDate | 1987-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d58297e35c47880965bc37f54808ea26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4da9260c5b79df9e7e770bed19440b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e4abf72be34c0cdf293e49624bb5477 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_931cd0b3a4582a851427ab72d1fc987c |
| publicationDate | 1996-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1563206-A1 |
| titleOfInvention | MIXED CIS-DIAMINDYCHLORODYHIDROXO COMPLEXES PLATINUM (IV), MANIFESTING ANTI-TUMOR ACTIVITY |
| abstract | The invention relates to complex compounds of platinum, in particular mixed cis-diamino dichloride and platinum (4+) complexes containing CH, CH; iso-CH or tert-butylamine and exhibiting antitumor activity that can be used in medicine. The goal is to create new active and more soluble compounds of the indicated class. Synthesis is carried out by oxidation of platinum alkylamine chloroamine chloro complex (2+) with HO in water when heated (10 minutes), followed by addition of MnO and keeping it for 2.5 hours at room temperature until the release of oxygen bubbles ceases. Then, after heating, the separation of the MnO filtrate is kept above the PO to reduce the volume by 4 times and the crystals of the target complex are separated. Yield,%: color, t.decomposed., C; solubility, mmol / l, electrical conductivity after 10 min and 48 h, cm / Ohm • mol: a) 57, pale yellow, 160; 26.2; 0.7; 2.3; b) 61; yellow, 185; 32.5; 2.4; 2.5; c) 74, pale yellow, 175; 20.9; 1.3; 3.1; d) 83, bright yellow 198, 14; 0.8; 3.1. These substances inhibit the development of sarcoma tumors and others by 86.9-96.3% at a dose of 20-25 mg / kg, versus 83% for oxoplatin. LD toxicity, mg / kg: a) 123; b) 128; c) 52; d) 22. 8 tab. |
| priorityDate | 1987-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.