http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1558927-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b0fa618adbd2f22784e90894365d89f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 |
| filingDate | 1988-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c6388945d4dffa2e7e4c815ff213c5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbb72a86cae4aad98cae4875ff3ef274 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6f7478fd809afcde4294a2501c79307 |
| publicationDate | 1990-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1558927-A1 |
| titleOfInvention | Method of obtaining hydrochloride of beta-6-aminohexylglicoside-acetyl nuramoil-l-alanyl-d-isoglutamine |
| abstract | The invention relates to peptides, in particular to the preparation of N-acetylmuramoyl-L-alanyl-D-isoglutamine β-6-aminohexylglucoside hydrochloride, which is used to prepare conjugates with synthetic and natural polymeric carriers. The goal is to increase the yield of the target product. The preparation is carried out by use in the synthesis of oxazoline as a starting material of 1,6-hexanediol obtained paratsetat β-6-N-acetylglucosamine gidroksilglikozid mesylated mesyl chloride in pyridine followed by conversion of the mesylate to azide benzilideniruyut benzaldehyde dimethylacetal without a solvent, is condensed with protected acid trifluoroacetate benzyl ester of L-ananyl-D-isoglutamine with N-oxysuccinimide and N, Nb-dicyclohexylcarbodiimide, benzylidene protection is removed by acid hydrolysis and hydrogenated over kisyu palladium in the presence of chloroform. The method allows to isolate the desired product as hydrochloride. The total yield of 22% (vs. 7% in the known method). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9710259-A1 |
| priorityDate | 1988-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.