http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1552605-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e558498fb21c085e32859f30201f1f63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 |
| filingDate | 1988-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b35b96d85b87ce18b20b269c150968ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1637b4714e889c3e22edd37cafc17b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_926665a5a5aefe447bfa59cb47e6b9c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b276401b8ba30f922e6ab32857a6a5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a265ae38216d4033f2d6df90a0afa7fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fae300cfd993a567614bb3f621c9e24e |
| publicationDate | 1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1552605-A1 |
| titleOfInvention | DIHYDROCHLORIDE 3- (2-DIMETHYLAMINOETHYLTHYO) -8-METHOXY-1,2,4-TRIAZINO [5,6-B] INDOLA, INCREASING HYPERTHERMIA STABILITY |
| abstract | The invention relates to heterocyclic compounds, in particular 3- [2-dimethylaminoethylthio] -8-methoxy-1,2,4-triazino [5,6-b] indole dihydrochloride, which increases resistance to hyperthermia. The goal is to create a more active substance of the specified class. Synthesis of lead from 3-mercapto-1,2,4-triazino [5,6-b] indole and 2-dimethylaminoethyl chloride hydrochloride at room temperature, followed by treatment with HCl. Gross l-CHNOS • 2HCl, yield 42.5%, so pl. 202С, LD = 580 mg / kg. With hyperthermia, a new substance with a dose of 10 mg / kg ensures the survival rate in a heat chamber (40C) of 75% of animals against 30% with a known bemithil. 1 tab. |
| priorityDate | 1988-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.