| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_592638d9e8f3946ee52e303f6335f38a |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 |
| filingDate |
1988-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1989-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45d0a0c172e1cdf125ad37d0a8353bbf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5840e43829f82e906703bd69b9d3e3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a05fe04b925bedbd86dd91cffed32d42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28cb7f86d2f9f74b82a20389da1c9002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5924b33996855383907ff0f54ca379b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38e50925f7e5e73d65c327928da03bcd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_937c6ab3458f5aef56159b1068b492e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66916c8a67eb10e4bad155c67d4cb71a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cc6e2dc5432dc091031268ac6c0b0a2 |
| publicationDate |
1989-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
SU-1532557-A1 |
| titleOfInvention |
Method of producing alpha-methylphenylalanine or alpha-benzylphenylalanine |
| abstract |
The invention relates to substituted amino acids, in particular to the preparation of α-methylphenylalanine or α-benzylphenylalanine, which are an intermediate in peptide synthesis. The goal is to increase the yield of the target product and simplify the process. Obtaining the desired products is carried out by dehydration of N-benzoylalanine or N-benzoylphenylalanine to obtain the corresponding oxazolin-5-one derivative, which is alkylated using benzyl bromide as the alkyl halide at elevated temperature and in dimethylformamide. The process is carried out in the presence of tetrabutylammonium iodide and potassium carbonate and the isolation of the target product is carried out by crystallization. Exit 80 - 83%. |
| priorityDate |
1988-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |