http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1528319-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 1985-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3181e06354278f7b30dbbfbd8a456f61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51fad05d1fd78d9da8f9e03e014135b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5abb3209af5346be048873ae1dd8722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b701003799064237741b7433439e1e6 |
| publicationDate | 1989-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1528319-A3 |
| titleOfInvention | Method of obtaining imidazole derivatives or their physiologically acceptable salts |
| abstract | The invention relates to imidazole derivatives, in particular the preparation of 1, 2, 3, 9-tetrahydro-9-methyl-3 - [(2-methyl-1H-imidazol-1-yl) methyl] -4H-carbazol-4-one or physiologically acceptable salts that are used in medicine. The goal is to create new substances with activity not characteristic of this class. Their synthesis is carried out by the reaction of substances total f l I and II: CH = CH-CH = CH-C = C-N (CH 3 ) -CH-CH-C (O) -CHY- (CH 2 ) 2 (I) and CH = CH- N = C (CH 3 ) -NH (II), where Y is methylene or CH 2 Z with Z is chlorine, dimethylamino or methanimino iodide group. The process is conducted by heating from 80 ° C to boiling. The resulting mixture of enantiomers is split, if necessary, and / or the base is converted to salt. New substances are antagonists of the "neuronal" receptors of 5-hydroxytryptamine (5HT) located on the main centripetal nerves. An effective dose of AU 50 = 2.5-11.6 mg / kg, a toxic dose 1000 times higher than AU 50 . 2 tab. |
| priorityDate | 1985-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.