http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1521738-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49e6d8f504fee44e8bb05bafe0e8eab3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 |
| filingDate | 1987-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e2cea2bace31656795e225cf94a947b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b128c85696a312480b071796897153c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24a140bb9753b9eef970809e95fb5a52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_405243e76e1834c9652ef3632e828ee0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9514bda7958e36baade7d831ab66506a |
| publicationDate | 1989-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1521738-A1 |
| titleOfInvention | Methyl-2-benzoyl-3-fluorine-3-desoxy-d-ribofuranozides as intermediate products in synthesis of biologically active 3ъ-fluorine-3ъ-desoxyribonucleosides |
| abstract | This invention relates to derivatives of sugars, in particular methyl- (2- or 2,5-Di) -0-benzoyl-3-fluoro-3-deoxy- (α or β) -D-ribofuranose, is propelling intermediates in the synthesis of Z 3 - fluoro-3 b -dezoksiribonukleozidov exhibiting cytotoxic activity. The goal is to create new intermediates for the synthesis of new active substances. The synthesis is carried out by the interaction of methyl 5-O-benzyl-2-O-benzoyl-3-fluoro-3-deoxy- (α or β) -D-ribofuranose with H 2 in the presence of a catalyst (5% palladium on carbon) in an alcohol medium in for 72 h. The obtained compound is treated with benzoyl chloride at 1-5 ° C, if necessary, and the mixture is stirred at 20 ° C for 10 h. Yield,%n n n @ mp. ° Cn n n gross formula: a) 97.2n n n 104-105n n n C 13 H 15 O 5 Fn n n b) 98n n n notn n n C 13 H 15 O 5 Fn n n c) 94.4n n n notn n n C 20 H 19 O 6 Fn n n d) 81.1n n n notn n n C 20 H 19 O 6 F. New intermediates make it possible to obtain new substances with cytostatic activity that exceed the activity of cyclocytidine by a factor of 11–22. 1 tab. |
| priorityDate | 1987-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.