| abstract |
6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula …<IMAGE>… is prepared by a process in which 2-iminopyrimidine derivatives containing [an] acyl and/or acyloxy group(s), of the formula …<IMAGE>… in which… R1 represents a hydrogen atom or a radical of the formula …<IMAGE>… in which formula… R denotes an alkyl radical or an aryl radical optionally substituted by a halogen atom,… R2 represents a hydroxyl group or a radical of the general formula …<IMAGE>… in which formula… R has the above meanings,… and… X represents a chlorine or bromine atom or an optionally substituted arylsulphonyloxy radical,… with the further proviso that,… in the case in which… R1 represents a hydrogen atom,… R2 is different from a hydroxyl group,… are reacted with piperidine and the 2-imino-4-piperidinopyrimidine derivatives containing [an] acyl and/or acyloxy group(s) obtained of the formula …<IMAGE>… in which… R1 and R2 have the above meanings… are hydrolysed. …<??>6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine has a hypotensive action. |