| abstract |
The invention relates to heterocyclic compounds, in particular 4-benzoyl-2,3-benzo-1,4,7,10-tetraoxacyclododecene-2, which has anticonvulsant activity, which can be used in medicine. The goal is to create new, more active compounds of the specified class. The synthesis of the target compound is carried out by the reaction of benzo-12-crown-4 and benzoic anhydride in polyphosphoric acid at 60-80 ° C (2.5 H). OUTPUT 70%, T.PL. 79-80 ° C, BRUTTO-FORMULA C 19 H 20 O 5 . NEW CONNECTION HAS A THERAPEUTIC INDEX 11.5 (AGAINST 7.0 FOR BENZO-12-KRAUN-4 AND 4.1 FOR SODIUM WALPROATA) WITH TOXICITY LD 50 = 654 MG / KG 1 TABLE |