| abstract |
The invention relates to derivatives of steroids, in particular compounds of the general formula R2 R where R, -C-Sf-alkyl dihydroindolip, pyridinyl, phenyl substituted with an alkylamino group or a kylamino-C-C4 alkyl group (in which nitrogen can be oxidized), pyrrolidinyl di-C, -C4-alkylamino-C-C-alkylthio, di-C-C-alkylamino-C-C, alkyloxy or trimethylsilyl group; R-C OH, CHjO, ethynyl, carbonyl, -C-NOH; H; C2-C4-alkenyl, C-C-alcadiene, C-C-alkynyl (may be substituted by “halogen, (CEj) Sit by lower alkenyl); B and C form a double bond or epoxy group that have pharmacologically valuable properties. The purpose of the invention is to create new substances with non-characteristic activity for this class. Synthesis of lead is carried out from the corresponding ketal (A is a ketal group, which can be cyclic or non-cyclic), which is dehydrated by cation-exchange sulfosmol or HC1. The crawled product is, if necessary, treated with hydroxylamine or, if R, is di-. The -C, -C4-alkylamino-C, -C-alkshphenyl, is oxidized, for example, with m-chlorophenbic acid to give the desired compound containing a group oxidized by nitrogen and 9,10-zipoxy. New substances exhibit a pronounced affinity for the glucocorticoid and progestogenic receptors, without showing activity at the mineralocorticoid and estrogen receptors with DC toxicity jd 100 mg / kg. 3 tab. i O) 4 4 :: S 00 co |