| abstract |
The invention relates to indole derivatives, in particular indolsulfonamide of the general formula, .. -dcj -) where K is —CHH — CH2 — C olOH; R - H. Halogen; R is CbH5 (it can be para-substituted by lower alkyl or halogen); RJ and R4 - And together or - connection, X - 1 or 2; Y-0 or I, or their alkaline salts, possess anti-asthma or antiallergic action, which can be used in medicine. The purpose of the invention is the creation of new active and low-toxic substances of the specified class. Their synthesis is carried out by treating unsubstituted indolic nitrogen with acrylonitrile in an inert solvent medium, followed by saponification and isolation of the target product containing a simple bond at (Rj + R4), or hydrogenating it in the presence of an acid and a reducing agent to isolate the product, where. The target product exudes sweat in free form or as an alkali metal salt, or mixture of isomers, or individual isomers. New substances delayed platelet aggregation and have low toxicity. 3 tab. § CO with co 00 O) o co |