| abstract |
The invention relates to hydrazine derivatives, in particular 1-difluoro-nitroacetum 1-2-aryl hydrazines, (FIG) of the general formula X-SvHd-W-Sh-K: that can be used in medicine. The goal is the creation of new, more active and non-causing side effects of substances of the specified class. The synthesis of FIG are carried out by the reaction of difluoronitroacetic acid methyl ester and the corresponding phenylgeneraine in ethanol at room temperature for 5 hours. Yield,% (v1, C) 47 (95-97); 44 (111); 45 (103). The toxicity of LDjo is 61.2-66.3 mg / kg. The vigorous potency of VNG is comparable to the activity of papaverine and Vlai than in dibazol and nilamide. The degree of blood pressure reduction was 31.3-53.2% versus 17.4-19.76%. In terms of the duration of action VNG is superior to the indicated substances - # 10 times In addition, VNG does not cause a decrease in heart rate. 1 tab. i (L |