http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1431678-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36089addd8e49e968b4c7e13c517dd1c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-30 |
| filingDate | 1985-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92f324d89cb4f6624b70f76de8c58149 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08fbeb1321af054fd4c0ae3dd7517aad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f155975322270962de37f4e58588698 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_774f4c4786287211d78a79d61c310ce7 |
| publicationDate | 1988-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1431678-A3 |
| titleOfInvention | Method of producing optically active ketals |
| abstract | The invention relates to heterocyclic compounds, in particular, to the preparation of optically active ketals of the formula I Br-SOch nL N SOPS QX Ar CH-RI X where Ar is phenyl, substituted by keel or halogen atom, naphthyl, substituted by lower alkyl, lower al- a coxy group or a halogen atom; R is C1-C4-alksh1; R and RS are the same, hydroxy, -OR4 or N is (Ry) (R) -group, where lower alkyl; Rj- and R are both C -C-alkyl; X is a C1, J or Br atom, a hydroxy group, a lower acyloxy group, a 4-methylphenylsulfonyloxy group or a lower alkylsulfonyloxy group; The carbon atoms marked with an asterisk are simultaneously in the R and S configurations that are used in medicine. The preparation of the target compounds is carried out from L (+) or B (-) - tartaric acid or its derivative R1-CO-CH (OH) -CH (OH) -CO-R3, where R and Rj have the indicated values, and the corresponding ketone or a ketal of the formula (R-, 0) (Ar) -C- (ORg) (CHX-R), where Ar, R, and X have their assigned meanings; R7 and Rg are C-C-alkyl, in a stream of inert gas in the presence of trifluoromethanesulfonic acid or tri-i alkyl chloroformate. at 50-90 ° C (in the case of using a ketone) or in the presence of thionyl chloride and methanesulphonic acid at 65-125 ° C (in the case of using ketal). The process is carried out with isolation of the desired product of the formula I, where, OR, ... or is converted into a compound of formula I, where, by the action of a strong base followed by acidification or prod: formulG I, where, translated into a compound of formula 1, where N (R5 ) (R), the action of amine. , § w Oil One F 1 oo s |
| priorityDate | 1984-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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