| abstract |
2,4-Disubstituted thiazole compounds of the formulan or a pharmaceutically acceptable acid addition salt thereof whereinn X is NH and Y is CH or N, or X is S and Y is CH; R 1 is certain straight or branched chain alkyl groups, (R 3 ) 2 C 6 H 3 , or (R 3 )Ar(CH 2 ) n where n is an integer from 1 to 4, R 3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R 2 is H or (Ci-C 4 )alkyl; or R1 and R 2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R 4 is H, (C 1 -C 5 )alkyl, NH 2 or CH 2 0H; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds. |