| abstract |
The invention relates to imidazole derivatives (PI), in particular compounds of the general formula I (O1n RI OR2 is | -sn, N where one of R and RJ is lower alkyl and the other is And or lower alkyl; R is lower alkyl; n O or 1; A - —O -) or -CR4R5-C (P) -C or -CR4R5-C (N-OR) -CRtR where R, RS R, lower alkyl; Rg-H or lower alkyl, or their salts with acids, which have the ability to inhibit the formation of ulcers and the release of acid in the stomach, which can be used in Medicine. The goal is to create new, more active substances of the specified class. PIs are synthesized by treating the corresponding nitrosubstituted compound (with NO-i instead of OR in compound I) with lower alkali metal alcoholate. The desired product (c n 0) is obtained directly, and at n 1 it is preliminarily oxidized. Isolation is carried out either as a base or as a salt. The toxicity of PI - LDJQ 7 1250 mg / kg. An effective dose, reducing the formation of sores, 1.2–6 mg / kg, reducing the secretion of acid in the stomach, 1.4–7.78 mg / kg (for known compounds, respectively, 1.6–79 and 1.07–10 mg / kg ), 2 tab. i (Y) With so and with O) SP |