http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1351938-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_af330e49f27592cd189400166c09ef79 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-073 |
| filingDate | 1984-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e493538f515e14bcd535ffd870088b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_862d6d0d0b11a7a8bed3b34c02040dc0 |
| publicationDate | 1987-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1351938-A1 |
| titleOfInvention | Method of triester synthesis of oligonucleotides |
| abstract | The invention relates to the chemistry of nucleic acids, in particular to the triester synthesis of oligonucleotides (ONT), which are used in biology and genetic engineering. The goal is to speed up the process. The synthesis of ONT is carried out by condensation of a 3-p-chlorofensh1 phosphate of a nucleoside or ONT with a protected nucleoside, nucleotide or oligonucleotide containing a free -OH group in pyridine under the action of a condensing agent (CA) and in the presence of a catalyst (CT). The QD used is 4-M, H-dimeshtyamino-pyridine-1-oxide, taken in a 3-fold molar excess relative to the CA. As the latter, 2,4,6-triisopropylbenzenesulfonyl chloride or 1- (2,4,6-triisopropylbenzenesulfonon1) -3-nitro-1,2,4-triazole are used. The method provides an increase in the rate of condensation of about 3 times. 1 hp f-ly, 1 ill., 2 tab. i O) OO SD with with 00 |
| priorityDate | 1984-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.