Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_592638d9e8f3946ee52e303f6335f38a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1582e7f75abd8ce770cfc1945455b08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06e2cd3d95a5bf6f59693ed40cc4042b |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
filingDate |
1986-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1992-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bc93b655d1c330de2b27769affe0cf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_828746a0ad15be1cd7725b7089db1b36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdd617d04c7d34da99bf997a4b3d81d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc00534142d31a0708cdf65ffa2e200 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af6709759eaa8c717a4612be4da4164c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d9ebea4539052fc31d2c8b21709da39 |
publicationDate |
1992-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
SU-1341949-A1 |
titleOfInvention |
1-(-d-xylofuranosyl)-5-trifluoromethyluracyl displaying antiherpetic activity |
abstract |
The invention relates to substituted furan, in particular 1 - (/ 5-B-xypofuranosyl) -5-trifluoromethyluracil (FM), which has antiherpetic activity and can be used in medicine. The goal is to create more active substances of this class. FM synthesis is carried out from 5-trifluoromethyluracil and hexamethylsilane in the presence of dimethyldichlorosilane at boiling followed by treatment with 1-0-acotch1-2.3, 5-tri-0-benzoyl - /} - B-xylofuranose in the presence of SnCl. The yield is 74.4%. Tests show that FM shows antiherpetic activity against a HSV-1 strain that is deficient in thymidine kinase and has a higher chemotherapeutic index than chdoxuridine (1.64 times). 2 tab. (L CO 4 CO 4 O |
priorityDate |
1986-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |