| abstract |
The invention relates to heterocyclic derivatives, in particular compounds of the general formula 1: F, C-CH, -NH-C (NH,). (CH,) -C (NHR2) NR, where X is 1,2,3-triazole, or pyrazole; R and R are linked together to form an unsubstituted imidazole or 5-methyl-1,2,4-triazole ring, or their salts with acids that are histamine H-2 antagonists, inhibit the secretion of gastric juice and use zyuy in medicine. In order to detect activity among compounds of this class, new I are obtained from a compound of formula II: F, C-CH2-NH-C (NH2) / -X- - (CH2). - C (OCHj) NH, where X is indicated above, and amino acetaldehyde dimethyl acetal or acetic acid hydrazide in methanol at room temperature followed by boiling of the reaction mass. I was isolated in free form or as salts with acids. Tests I show a better antagonistic effect than the known cimetidine. 1 tab. i О) оо а СП а 1сн |