http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1299500-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef7079abdd69a7a1996c43f08fe1111 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C5-00 |
| filingDate | 1983-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e80204efe6142377973818cdbc6e7b40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a13506501709c1a92d225ad3ef2a05c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e089eaab57e67575a8f7e87919526b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52ee793b5819f08681841e5c4234afa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a8332113cfc6e15aa5708ba1270a1ff |
| publicationDate | 1987-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1299500-A3 |
| titleOfInvention | Method for producing derivatives of 1-aryl-2-aminoethanol-1 |
| abstract | The invention relates to amino alcohol derivatives, in particular 1-aryl-2-aminoethanol-1 (AE) of the general formula (I): X-Ar-CR (OH), jR, where Ar is phenyl or naphthyl, benzo-1,3- dioxane, thienyl; X - And, C1, Br, lower alkyl, alkoxyl, NOj; K - lower alkyl, H; K and RJ - H, lower alkyl, phenyl, phenylethyl, which are used for the synthesis of biologically active compounds. The purpose of the invention is the creation of a universal method, providing a wider range of compounds of the specified class. The synthesis of AE includes the steps of: a) reacting a sulfide of the general formula (II): R-SCHj, where is n-alkyl, with dimethyl sulfate in a water-immiscible organic solvent (); b) adding to the reaction mixture first an alkali in the presence of a catalyst, tetrabutylammo bromide, and then a carbonyl compound of formula (III): X - Ar - CR, (0), where X, Ar, R, are indicated above; c) removing water and / or part of an organic solvent and treating the residue with an amine of the general formula (IV):, where F, and F are as above. The method provides AE in the form of hydrochloride with a yield of 60-75%. with (oh w x with sp about o see |
| priorityDate | 1982-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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