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filingDate 1982-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1986-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a317a1c86c4643c7683e304d16a40eb
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publicationDate 1986-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SU-1222197-A3
titleOfInvention Method of producing bicyclic compounds or stereoisomers of the compounds or their pharmaceutically acceptable salts with acids
abstract New bicyclic compounds of the general formula (I), <IMAGE> (I) wherein R1 and R2 each represent a C1-6 alkyl group, and R3 is an etherified hydroxy group of the formula -CR4, wherein R4 is benzyl group, benzhydryl group or a phenyl group bearing optionally a phenyl or a trihalomethyl substituent or one or more halogen substituent(s), or R3 is an esterified hydroxy group of the formula -OCO-R5, which represents a phenyl-(C1-5 alkyl)-carbonyloxy group, a cinnamoyloxy group having optionally a halogen or one or more C1-4 alkoxy substituent(s), a benzoyloxy group having optionally a C1-4 alkyl, phenyl or trihalomethyl substituent or one or more C1-4 alkoxy substituent(s), one or more halo substituent(s) and/or nitro substituent, a benzyloyloxy group, a xanthene-9-carbonyloxy group, an optionally substituted naphthoyloxy group, or an acyloxy group derived from a five- or six-membered heterocyclic carboxylic acid bearing optionally a halo substituent on the ring, are prepared by etherifying or esterifying a bicyclic compound of the general formula (II), <IMAGE> (II) wherein R1 and R2 are as defined above. The new compounds according to the invention possess anti-arrhythmic effects and can be applied to advantage in the therapy of cardiac rhythm disorders.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2503663-C2
priorityDate 1981-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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