| abstract |
1. METHOD FOR OBTAINING 2,3,4-TRINOR-M-INTER-FENSHNG PROTAGLANDINE DERIVATIVES of the general formula j daoRi, CgO where R is alkyl with 1-4 carbon atoms, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation; R2, .HR independently of each other. are hydrogen, alkanoyl with 1-4 carbon atoms, tetrahydropyranyl, ethoxyethyl or trialkylsilyl group, where alkyl with 1-4 carbon atoms; R, hydrogen or alkyl with 1-4 carbon atoms; To a hexyl, heptyl, phenoxymethyl, m-trifluoromethylphenoxymethyl group or a group of the formula -CH-Rg I ° Z where Z is an amino group, an alkanoyl amino group with 1-4 carbon atoms, benzoylamino or thozi Rg is an alleino group, and a kil with 4-6 carbon atoms, 0) phenyl or benzyl, characterized in that the bicyclic lactol of the general formula UN g CgO where EL-RK have the indicated meanings, are reacted with a phosphorane obtained from the phosphonium salt of the 9-complete formula (III) I PH3P CHXxxX COHon where Ph is phenyl; X is a monovalent anion, under the action of a strong base in a dipolar aprotic solvent. |