abstract |
The method of producing 5-substituted oxazolidine-2,4-dion derivatives of the general formula I R Y V ° o -H-RI where R is a hydrogen atom, acetyl, C -Cj-alkylcarbamoyl, cyclohexylcarbamoyl or C -C alkoxycarbonyl; RI is a group of formula where Z is a chlorine atom or trifluoromethyl; Z is a chlorine atom, methyl, C-Cd-Alft} rmethyl; Z "a hydrogen or halogen atom, methyl or C -C-alkoxyl; Z is a hydrogen or halogen atom, methyl, and a nitro group or an alkoxy, provided that when R is a hydrogen atom, 2 is different - the photon of a hydrogen atom, and Z and Z. together are not methyl; 7 -fc a hydrogen or fluorine atom, or a nitro group; U-, hydrogen or fluorine atom; 1, C-C - alkoxy or methyl, benzyloxy group; a y, hydrogen or methoxyl, C as a paramame or optically active izscher in free form or as a pharmaceutically acceptable salt, and when R is a hydrogen atom, characterized in that the compound of general formula II 1C BUT KNy - OR 00 00 00 R, S where RJ roieeT is the indicated value; R J - C -Cj-alkyl, is reacted with phosgene in an inert organic solvent medium and the resulting compound of the general formula III O n O I and OR, R |