http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SU-1093244-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76646d99f8b5d425aec8b6bc4e333e70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5575 |
| filingDate | 1981-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19b87050c009756dc12fca8e0fb9f73e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9550cc5561365cd6b7527d60aac3acfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be67da9a4341a4a0c18f8a41a693f8dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b033ed4f1298517e19429b3bbe1deb8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53d680b663568f8335382aea64924881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a28dd74d2c5a4c2ec4738e976867d661 |
| publicationDate | 1984-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SU-1093244-A3 |
| titleOfInvention | Process for preparing derivatives of 16-amino-18,19,20-trinor-prostaglandine or their acid addition salts |
| abstract | 1. A method for producing 16-amino-18,19,20-trinor-prostaglan i dine derivatives of the general formula (1) doofy | HO where C are atoms in positions 15 and 16 can be in the .S or R configuration, Y - hydrogen or lower alkyl-, W - hydrogen, halogen, hydroxyl, lower alkyl or apkoxyl, or their acid addition salts, characterized in that in derivative 9c, oLf 15-TRIOXI-16-p-nitrocarbobenzoxido-17-phenyl- 5-cis, 13-trans-18,19,20-trinor-prostadiene acid of the general form -. where (C) atoms in the 15 and 16 positions. can be in the S or R configuration, W has the indicated values, Y is lower alkyl, remove the o-nitrocarbobenzoxygruypu to obtain compounds of formula (I), where Y is lower alkyl, or the p-nigroi carboxy group and the ester group are removed in any sequence to form the fordyl formula (I), where Y is hydrogen, followed by free-radical separation of the target product or the acid additive. 2. Method POP1, characterized in that the p-nitrocarbenzoxy group is removed by reduction; it is diluted with acetic acid. 3. Method according to claims 1 or 2, about tl and ND 4 due to the fact that ester. the group is removed by hydrolysis in the presence of an alkali metal hydroxide, preferably lithium hydroxide, in a mixture of a lower alkanol, preferably methanol, and water. 4. A method according to or 2, characterized in that the ester group is enzymatically removed in the presence of an esterase, preferably a lipase. |
| priorityDate | 1981-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.