| abstract |
Thio etianic acid derivatives of the formulan whereinn X' is hydrogen, fluoro, or chloro; X 2 is hydrogen, fluoro, chloro or bromo; X 3 is =C=O Cln may also be =C when X 2 is chloro; H R is alkyl of 1 to 6 carbon atoms, or phenyl or benzyl optionally substituted with a substituent on the phenyl ring which is alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon _ atoms or halo; R 1 is hydrogen or alkanoyl of 2 to 6 carbon atoms when R 2 is hydrogen, a-methyl or β-methyl or OR 1 and R 2 together are 16a, 17a-isopropylidenedioxy; and the solid and broken lines between C-1 and C-2 represent a double or single bond; are useful an anti-inflammatory steroids. They can be prepared by reacting the corresponding 17β-carboxylic acid or a reactive derivative thereof with an alkali metal salt of RSH. |