| abstract |
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin D3, and Vitamin D3 derivatives which are capable of activating the intracellular Vitamin D3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent. The immune response augmenting agent enhances T cell lymphokine production. Suitable immune response augmenting agents include, but are not limited to, DHEA and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16- alpha -bromo-DHEA, 7-oxo-DHEA, 16- alpha -bromo-DHEA-S, and 7-oxo-DHEA-S. |