abstract |
The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxine B with yield from 1,8 to 2,8 g/1 of filtrate of fermentation broth at temperature 28°C, pressure 40 - 70 kPa, aeration from 0,4 to 1 vvm, concentration of dissolved oxygen minimal 60%, maintenance of pH and optimal concentration of glucose and ammonia ions. |