| abstract |
New cyclic peptide(s) that inhibit integrin receptor interaction CyclopeptidesCompound of general formula (I) Cyclo-(Arg-Gly-Asp-R1), wherein R is o-aminomethyl-o'-carboxylbiphenyl (Biph), 2-aminomethyl-5-carboxymethylthiophene (Act) or 2-carboxy-8-amino-4-thiapiperolidin-9-one (Btd); and their physiologically suitable salts in the form of enantiomer or diastereomer, which is an inhibitor of integrin and is usable for prevention and treatment of diseases of circulation, bones, tumours, as antiviral and antimicrobial preparation. Disclosed is also method for production fo the said compositions, their use as the medicament and for preparation of the immobolised ligands for purificn. of intergrins by affinity chromatography. |