| abstract |
A method of lowering plasma levels of Lp(a) or inhibiting the generation of apo(a) in a human by administering an effective amount of a compound of formula (I) wherein: R<1> is hydrogen or alkyl; A, B, D, E, G, R<2> and R<3> each are hydrogen, and R<4> is hydrogen in the beta -position; or R<2> with R<4>, R<4> with A, A with R<3>, B with D, D with E, or G with R<2> is a bond, and the other substituents are each hydrogen; or R<2> is alkyl in the beta -position and A, B, D, E, G, R<3> and R<4> are each hydrogen; or R<3> is alkoxy in the beta -position and A, B, D, E, G, R<2> and R<4> are each hydrogen; or R<4> is hydrogen in the alpha -position and A, B, D, E, G, R<2> and R<3> are each hydrogen; and R<5> is methyl or ethyl, is disclosed. |