| abstract |
The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:n nwherein: R 1 and R 2 are, independently, selected from H; C 1 -C 12 alkyl or C 1 -C 6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R 3 , R 4 , R 5 , and R 6 are independently selected from H, halogen, - NO 2 , alkyl ; alkoxy, C 1 -C 6 Perfluorinated alkyl, OH or the C 1 -C 4 esters or alkyl ethers thereof, -CN, -O-R 1 , -O-Ar, -S-R 1 , -S-Ar, -SO-R 1 , -SO-Ar, -SO 2 -R 1 , -SO 2 -Ar, -COR 1 , -CO-Ar, -CO 2 -R 1 , or -CO 2 -Ar; and Y is selected from a) the moiety:n nwherein R 7 and R 8 are independently selected from the group of H, C 1 -C 6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C 1 C 4 alkyl)-, -N=, and -S(O) n -. |