http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SK-512003-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate | 2001-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f47aa5644e0bbef016ea62866a714e14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d94f4814ef02d5431a14c211071834e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2460a29110192bb31cbc52499f4ac3da |
| publicationDate | 2003-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SK-512003-A3 |
| titleOfInvention | Indole derivatives useful for the treatment of CNS disorders |
| abstract | The present invention relates to an indole derivative having the formula wherein Y is CO, CS, SO, SO2 or CH2; Z is CO, CS, SO, SO2 or CH2; provided that only one of Y and Z is CO, CS, SO or SO2; W is a bond, O, S, CO, CS, SO or SO2; n is 0-5, m is 0-5 and n+m is 1-6; provided that when W is O or S, then n>=2 and m>=1, when W is CO, CS, SO or SO2, then n>=1 and m>=1; X is N or CH and the dotted line represents no bond, or X is C and the dotted line represents a bond; one of R1, R2, R3 and R4 forms a bond to X and the others of R1, R2, R3 and R4 and R5 and R7-R12 are selected form hydrogen, halogen, cyano, nitro, amino, C1-6-alkyl-amino, di-(C1-6-alkyl)-amino, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, acyl, thioacyl, trifluoromethyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl; and R6 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, acyl, thioacyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl; or pharmaceutically acceptable salts thereof. The compounds of the invention are potent dopamine D4 ligands. |
| priorityDate | 2000-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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