http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SK-50999-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc4cd15dbee579bf2da8bc8e45f0b00f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 |
| filingDate | 1997-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0980a886f5461648378f5f77a0d20379 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20bebc2e81cc460952d19bc5884dad03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a688c9128a08f63d4fbe24635e42e67f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4b2bac2fc314410e9394d712866e9b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_566ef79e63a5985657b83b2df0c32dbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b90ddb140503d25cf8d076cd7012ca8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6359dd5a44e5e6b91bbe63dde684d916 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08d947993a77e57e95525d51be37c96c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16453413cd47c9cd5a3b976ca27cf543 |
| publicationDate | 2000-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SK-50999-A3 |
| titleOfInvention | Anthranilic acid derivatives as multi drug resistance modulators |
| abstract | An anthranilic acid derivative of formula (I), wherein: each of R, R1 and R2, which are the same or different, is H, C1-C6 alkyl, OH, C1-C6 alkoxy, halogen, nitro, or, N(R1OR11) wherein each of R1O and R11, which are the same or different, is H or C1-C6 alkyl, or R1 and R2, being attached to adjacent positions of ring b, together form a methylenedioxy or ethylenedioxy group; R3 is H or C1-C6 alkyl; R4 is C1-C6 alkyl or R4 represents -CH2- or -CH2CH2- which is attached either (i)tto position 2 of ring b to complete a saturated 5- or 6-membered nitrogen-containing ring fused to ring b or (ii)tto the position in ring a adjacent to that to which X, being a single bond, is linked, thereby completing a saturated 5- or 6-membered nitrogen-containing ring fused to ring a; R5 is H, OH or C1-C6 alkyl; X is a direct bond, 0, S, -S-(CH2)p- or -0-(CH2)p- wherein p is an integer of 1 to 6; R6 is H, C1-C6 alkyl or C1-C6 alkoxy; q is 0 or 1; Ar is an unsaturated carbocyclic or heterocyclic group selected from furan, thiophene, pyrrole, indole, isoindole, pyrazole, imidazole, isoxazole, oxazole, isothiazole, thiazole, pyridine, quinoline, quinoxaline, isoquinoline, thienopyrazine, pyran, pyrimidine, pyridazine, pyrazine, purine and triazine which is unsubstituted or substituted by one or more substituents selected from OH, halogen, C1-C6 alkyl, which is unsubstituted or substituted by halogen, C1-C6 alkoxy, nitro and N(R1OR11); each of R7 and R8, which are the same or different, is H, C1-C6 alkyl which is unsubstituted or substituted by one or more halogen atoms, C1-C6 alkoxy, hydroxy, halogen, phenyl, NHOH, nitro, N(R1OR11), or SR12 wherein R12 is H or C1-C6 alkyl; or R7 and R8, when situated on adjacent carbon atoms, form together with the carbon atoms to which they are attached a benzene ring or a methylenedioxy substituent; R9 is phenyl or an unsaturated heterocyclic group selected from furan, thiophene, pyrrole, indole, isoindole, pyrazole, imidazole, isoxazole, oxazole, isothiazole, thiazole, pyridine, quinoline, quinoxaline, isoquinoline, thienopyrazine, pyran, pyrimidine, pyridazine, pyrazine, purine and triazine, each of which is unsubstituted or substituted by C1-C6 alkyl, OH, C1-C alkoxy, halogen, C3-C6 cycloalkyl, phenyl, benzyl, trifluoromethyl, nitro, acetyl, benzoyl or N(R1OR11), or two substituents on adjacent ring positions of the phenyl or heterocyclic group together complete a saturated or unsaturated 6-membered ring or form a methylenedioxy group; n is 0 or 1; and m is 0 or an integer of 1 to 6; Also disclosed are pharmaceutical compositions containing the above compound that can be used as an inhibitor of p-glycoprotein. The compound is useful as a modulator for multidrug resistance, for potentiating the cytotoxicity of a chemotherapeutic agent or enhancing the net absorption, distribution, metabolism or elimination characteristics of a therapeutic agent |
| priorityDate | 1996-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 496.