| abstract |
2,3-benzodiazipine derivatives of general formula (I), wherein R1 and R2 are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, nitro, trifluoromethyl, or NR8R9, wherein R8 and R9 are independently hydrogen, C1-6 alkyl, or -COR10, wherein R10 is hydrogen alkyl, substituted by at least one C1-4 alkoxy and/ or at least one halogen group, C6-10 aryl, C1-4 alkoxyl, C3-5 cycloalkyl, C2-6 alkenyl, C3-5 cycloalkoxyl or a group of formula -NR11R12, wherein R11 and R12 are independently hydrogen, C1-4 alkyl, C3-5 cycloalkyl or C6-10 aryl, R3 represents C1-4 alkyl, C3-5 cycloalkyl or a group of formula -CO-R13, wherein R13 is same as defined R10; R4 and R5 are independently hydrogen or C1-3 alkyl; R6 and R7 are independently hydrogen, chlorine or bromine under the condition that till one of R6 and R7 is hydrogen, second substituent is other than hydrogen, their isomers and acid additive salts; pharmaceutical compositions, containing said derivatives and their use; production method of derivatives of general formula (I) and initial compounds of formula (II), wherein R1, R2, R3, R4, R5, R6 and R7 are of the said meaning. |