| abstract |
Disclosed is a variant of neublastin polypeptide with introduced site for polyalkylene glycol attachments. Further are: a fusion protein comprising the aforementioned variant neublastin polypeptide; neublastin polypeptide variant; a vector containing the nucleic acid; a host cell said said vector; a method of making the aforementioned variant of neublastin polypeptide; a conjugate of neublastin variant polypeptide or fusion protein containing the same with polyalkylene glycol; a pharmaceutical composition is said to be a variant of neublastin polypetide, said fusion protein or said conjugate with polyalkylene glycol and their medical use. |