abstract |
Described is the use of aryl moieties to which a molecule to be transferred is selected from a polynucleotide, an oligonucleotide or a mononucleotide, to transfer the molecule through a biological membrane in vitro, and to use it to prepare a medicament for preventing and / or treating diseases associated with expression or overexpression of certain genes, and / or diagnosis for diagnosis or early identification of such diseases. The aryl radical (s) is (are) attached to the 5'-end, the 3'-end, the heterocyclic base, the sugar or the internucleoside bridge and can also be attached / attached via nucleotide building blocks. The aryl radical to which the molecule to be transferred is selected from a polynucleotide, oligonucleotide or mononucleotide is incubated with the membrane. Subsequently, the conjugate is transferred to the cell without cleavage of the aryl radical. The cell is a eukaryotic or prokaryotic cell. |