| abstract |
Highly preserved, immunologically available antigen on the surface of Neisseria meningitidis microorganisms. Immunotherapeutic, prophylactic and diagnostic compositions and methods useful in the treatment, prevention and diagnosis of diseases caused by Neisseria meningitidis. Proteinase K resistant Neisseria meningitidis surface protein having an apparent molecular weight of 22 kDa, corresponding nucleotide and amino acid sequences (SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7; SEQ ID NO: 2) , SEQ ID NO: 4, SEQ ID NO: 6 and SEQ ID NO: 8), recombinant DNA methods for producing the Neisseria meningitidis 22 kDa surface protein, and antibodies that bind to the Neisseria meningitidis 22 kDa surface protein. |