| abstract |
Disclosed are combretastatin A-4 phosphate derivatives based on mono- and disols, optionally substituted aliphatic organic amines, mono- and disols of amino acids and mono- and disols of amino acid esters, these salts having greater solubility than natural combretastatin A-4 and under physiological conditions rapidly regenerate combretastatin A-4. Also described is the use of these compounds for the manufacture of a medicament for modulating the growth of a tumor or metastasis in an animal, a pharmaceutical composition thereof, and a process for their preparation. |