| abstract |
Disclosed are pyridazinone compounds of formula (I), which are cyclooxygenase inhibitors, in particular are selective cyclooxygenase-2 (Cox-2) inhibitors, an inducible isoform associated with inflammation as opposed to constitutive isoform, cyclooxygenase-1 (Cox-1) is an important enzyme-maintaining state in many tissues including the gastrointestinal tract (GI) and kidneys. The selectivity of these compounds for Cox-2 minimizes undesirable side effects in the GI and the renal region, which are in the commonly sold non-steroidal, anti-inflammatory drugs (NsaID). |