| abstract |
A process for the preparation of R - (+) - 6-carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole or a salt or solvate thereof comprising: a) resolution of an enantiomeric mixture of 6-cyano-3-N- methylamino-1,2,3,4-tetrahydrocarbazole by treatment with L-pyroglutamic acid to give R - (+) - 6-cyano-3-N-methylamino-1,2,3,4-tetrahydrocarbazole or a salt or solvate thereof and hydrolysis of R - (+) - 6-cyano-3-N-methylamino-1,2,3,4-tetrahydrocarbazole or a salt or solvate thereof, optionally followed by salt formation. |