| abstract |
Described are substituted Mannich bases of pyrrols of formula (I) wherein R 1 = H, C 1-10 -alkyl, aryl, heteroaryl or aryl, heteroaryl, CN, Br, Cl or OH radical bonded via a C 1-6 -alkylene group, R 2 = CH (R 4) N (R 5) (R 6), R 3, R 3 ', R 3' 'together or individually represent H, F, Cl, Br, CF 3, CN, NO 2, SO 2 NH 2, NHR 7, SR 8, OR 9, CO ), CH2CO (OR11), COR15, C1-10-alkyl-, aryl-, heteroaryl aryl radical or heteroalkyl radical bonded via C1-6-alkylene, R4 = unsubstituted phenyl radical or phenyl radical which is at least monosubstituted C1-4 alkyl, C 1-3 -alkoxy, halogen, a process for the manufacture of said compounds, medicaments comprising said compounds, and the use of said compounds for the manufacture of a medicament. Said active compounds are particularly suitable for the treatment of pain and for the treatment of inflammatory diseases and allergic reactions, drug or alcohol addiction, diarrhea, gastritis, ulcer, cardiovascular disease, urinary incontinence, depression, shock conditions, migraine, narcolepsy, overweight, asthma, glaucoma , hyperkinetic syndrome, lack of will (taste) to do something, bulimia, anorexia, catalepsy, anxiolysis, to increase alertness and / or to increase libido. |