| abstract |
Described is an isolated nucleotide sequence encoding a polypeptide with at least 80% sequence identity to a self-acid sequence selected from the group consisting of SEQ ID NO: 17 and SEQ ID NO: 21, wherein said polypeptide interacts with a Ret receptor protein, triggers dimerization of the Ret receptor protein or autophosphotylation of a receptor tyrosine kinase domain of the Ret protein. Further disclosed is a vector comprising said nucleic acid, a host cell comprising a vector, a polypeptide encoded by said nucleic acid, a method of preparing a polypeptide, and an isolated monoclonal antibody. |