| abstract |
Process for the solid-phase synthesis of ketones and aldehydes of general formula (I) and (II) by reacting a polymeric resin N-alkylated hydroxamic acid of formula (III) with an organometallic compound of formula RcM in the case of ketone synthesis or reducing agent in the case of aldehyde synthesis and separation of ketone or . aldehyde from the resin. R a, R b and R c in formulas (I), (II) and (III) are aliphatic or aromatic; L in formula (III) may be absent or, if present, is a linking group. Also described are methods for preparing a polymeric resin N-alkylated hydroxamic acid of formula (III). |