| abstract |
Disclosed is a chimeric antibody that binds specifically to a human antigen, is non-immunogenic in humans and is not the same as a human or chimpanzee antibody, and which comprises light heavy chain polypeptides each comprising: a variable region having an amino acid sequence of a variable region Old world monkey antibodies from rhesus monkeys, cynomolgus monkeys and baboons, a constant region having the amino acid sequence of a human or chimpanzee antibody constant region. Also described is a pharmaceutical composition containing the same, a process for its manufacture and use. |