| abstract |
Described are compounds of formula (I), their N-oxide forms, their pharmaceutically acceptable acid addition salts, and their stereochemically isomeric forms, wherein L is a group of formula a, b, c, d, e or f wherein Alk independently represents optionally substituted C1 -6 alkanediyl, n is independently 1, 2 or 3; Y is O, S or NR 2; R 1 represents hydrogen, aryl, Het 1 or optionally substituted C 1-6 alkyl; R 2 independently represents hydrogen or C 1-6 alkyl; or when R 1 and R 2 are attached to the same nitrogen atom, they may together form a heterocyclic group or together may form an azide group; R 3 is each independently hydrogen, hydroxy or C 1-4 alkyloxy: aryl is phenyl, naphthalenyl, 1,2,3,4-tetrahydronaphthalenyl, idenyl or indanyl; each of said aryl groups may be optionally substituted; Het 1 represents an optionally substituted monocyclic or bicyclic heterocyclic group; Het2 has the same meaning as Het1 and can also be piperazinyl, homopiperazinyl, 1,4-dioxanyl, morpholinyl, thiomorpholinyl; R 6 represents hydrogen or C 1-4 alkyl; R 7 is hydrogen or C 1-4 alkyl or R 6 and R 7 co-form a bivalent group -N = CH- (i), -CH = N- (ii), -CH = CH- (iii), -CH 2 -CH 2 - (iv) wherein one hydrogen atom in groups (i) and (ii) may be replaced by C 1-4 alkyl and one or more hydrogen atoms in groups (iii) and (iv) may be replaced by C 1-4 alkyl; D is a 1,3-dioxolane derivative; as antifungal agents, processes for their preparation, compositions containing them and their use as medicaments. |