| abstract |
The piperidines of formula (I), their N -oxide forms, pharmaceutically acceptable addition salts, and stereochemically isomeric forms thereof, wherein Alk represents a C 1 -C 6 alkanediyl group; n is 1 or 2; X 1 is -O-, -S (= O) -, or -S (= O) 2 -; each R 1 independently represents a hydrogen atom, a halogen atom, a C 1 -C 6 alkyl group, a nitro group, a hydroxy group or a C 1 -C 4 alkoxy group; D represents an optionally substituted mono-, bi- or tricyclic nitrogen-containing heterocycle, 2H-benzopyranone, benzamide, benzophenone or phenoxyphenyl; processes for their preparation, compositions containing them and their use as medicaments. Tricyclic delta 3-piperidines have antagonistic activity on the central alpha2-adrenoceptor. |