| abstract |
Polypeptides are described which are variants of the lipase-stimulated bile salts (BSSL, EC 3.1.1.1), DNA molecules encoding these polypeptides, methods of making these BSSL variants and producing non-human transgenic mammals capable of expressing BSSL variants. Also disclosed are transgenic non-human mammals, as well as infant formula containing milk from the transgenic animals described, pharmaceutical compositions containing the polypeptides, and the use of said polypeptides and DNA molecules for the manufacture of a medicament. |