| abstract |
The composition comprises an inert core, a soluble active layer, or a layer that rapidly disintegrates in water and is prepared from an aqueous or hydroalcoholic suspension-solution containing the active ingredient having an anti-ulcer activity of formula (I), (II) or (III); and an gastric-resistant outer coating, which is prepared from a solution comprising an enteric coating polymer and at least one additive. The method of preparing the composition comprises the following steps: spraying the inert core with a single aqueous or hydroalcoholic solution-suspension, spray drying the active layer formed in the preceding step; spraying the active core with a solution comprising an enteric coating polymer with at least one pharmaceutically acceptable excipient to form a gastric-resistant outer coating. |