| abstract |
Anthranilic acid derivatives are described as modulators of resistance to many drugs of formula (I) and their pharmaceutically acceptable salts, wherein each of R 1 to R 9 are organic substituents, n is 0 or 1, m is 0 or an integer from 1 to 6, q is 0 or 1, X is a direct bond, O, S, -CH 2 - (CH 2) p - or -O- (CH 2) p -, wherein p is an integer from 1 to 6 and Ar is an unsaturated carbocyclic or heterocyclic group, which are active as P-glycoprotein inhibitors and can also be used as modulators of multidrug resistance in the treatment of multidrug resistant tumors. Also described is a process for the preparation of these compounds and a pharmaceutical or veterinary preparation containing them |