| abstract |
Disclosed are compounds of formula (I) wherein B, D, E, R, W, Y, Z, b, c, d, e, f, g and h are as defined in the claims, are leukocyte adhesion and migration inhibitors, and / or VLA-4 adhesion receptor antagonists belonging to the integrin family, pharmaceutical compositions containing them, and the use of compounds of formula (I) for the preparation of medicaments for the treatment or prophylaxis of diseases caused by an undesirable extent of leukocyte adhesion and / or leukocyte migration, or associated with an unwanted range of leukocyte adhesion and / or leukocyte migration, or where cell-cell or cell-matrix interactions play a role based on the interaction of VLA-4 receptors with their ligands, such as inflammatory processes, rheumatoid arthritis or allergic diseases |