http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SK-283952-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 1996-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24a12a88e7c4b126f6580c878b617828 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_972249414b35618edc2c70c29d413bea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad6493cebfdf4d6db438ea26f6f33e8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f000dec13856a43b42397703c0b45d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f42350c72c43d886e98c714600611fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81f4a3ae13f8bc71b05d8f3e42091b64 |
| publicationDate | 2004-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SK-283952-B6 |
| titleOfInvention | Pyrido [2,3-D] pyrimidines and pharmaceutical compositions based thereon |
| abstract | Pyrido [2,3-D] pyrimidines of formula (I) wherein X is NH, N-acyl, O or S; R 1 is NR 3 R 4, SR 3, OR 3, SOR 3 or SO 2 R 3; each of R 2, R 3 and R 4 is independently H, (CH 2) n Ph, wherein Ph is optionally substituted phenyl and n is 0, 1, 2 or 3; cycloalkyl of 3 to 6 C, alkanoyl of 1 to 6 C, alkyl of 1 to 6 C, alkenyl of 2 to 6 C or alkynyl of 2 to 6 C, these alkyls, alkenyls and alkynyls optionally substituted with NR 5 R 6, optionally substituted phenyl , (1-6C) thioalkyl, (1-6C) alkoxy, hydroxyl, carboxyl, halogen or (3-6C) cycloalkyl, wherein R5 and R6 are each independently H, (1-6C) alkyl, (2-6C) alkenyl; , 2-6C alkynyl, (CH2) nPh, wherein Ph is optionally substituted phenyl and n is 0, 1, 2 or 3 or 3-6C cycloalkyl or R5 and R6 taken together with the nitrogen atom to which they are attached, they may complement a ring of 3 to 7 C atoms and optionally containing 1, 2 or 3 heteroatoms selected from N, O and S; wherein R 4 can also be -C (= O) R 3, -C (= O) R 3, -SO 2 R 3, -SO 2 NR 5 R 6, -C (= O) NR 5 R 6, -C (= S) NR 5 R 6, -C (= NR) R 3 or -C (= NH) NR 5 R 6; and R 3 and R 4 taken together with the N to which they are attached may additionally complement a ring containing 3 to 7 C atoms and optionally containing 1, 2 or 3 heteroatoms selected from N, O and S; Ar is phenyl or substituted phenyl; and pharmaceutically acceptable salts thereof. These compounds are useful for the inhibition of protein kinases and are thus effective in the treatment of cell proliferative diseases, atherosclerosis, restenosis, psoriasis and cancer. Pharmaceutical compositions based on these compounds |
| priorityDate | 1995-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 672.